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aromatase  (Molecular Dynamics Inc)

 
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    Structured Review

    Molecular Dynamics Inc aromatase
    Overlay of the binding poses of compounds 5c , 5e and 5f with the <t>aromatase</t> enzyme. Two-dimensional and three-dimensional interaction profiles of derivatives 5c ( A ), 5e ( B ), and 5f ( C ) with the active site of aromatase (PDB ID: <t>3EQM).</t> Note: High-resolution and enlarged versions of these figures are available in the for detailed inspection .
    Aromatase, supplied by Molecular Dynamics Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/aromatase/aromatase/pmc12943600-158-15-0
    Average 86 stars, based on 1 article reviews
    aromatase - by Bioz Stars, 2026-10
    86/100 stars

    Images

    1) Product Images from "Design, Synthesis, Biological Evaluation and Molecular Docking Studies of New N -Heterocyclic Compounds as Aromatase Inhibitors"

    Article Title: Design, Synthesis, Biological Evaluation and Molecular Docking Studies of New N -Heterocyclic Compounds as Aromatase Inhibitors

    Journal: Pharmaceuticals

    doi: 10.3390/ph19020224

    Overlay of the binding poses of compounds 5c , 5e and 5f with the aromatase enzyme. Two-dimensional and three-dimensional interaction profiles of derivatives 5c ( A ), 5e ( B ), and 5f ( C ) with the active site of aromatase (PDB ID: 3EQM). Note: High-resolution and enlarged versions of these figures are available in the for detailed inspection .
    Figure Legend Snippet: Overlay of the binding poses of compounds 5c , 5e and 5f with the aromatase enzyme. Two-dimensional and three-dimensional interaction profiles of derivatives 5c ( A ), 5e ( B ), and 5f ( C ) with the active site of aromatase (PDB ID: 3EQM). Note: High-resolution and enlarged versions of these figures are available in the for detailed inspection .

    Techniques Used: Binding Assay

    Related Articles

    Membrane:

    Article Title: Design, Synthesis, Biological Evaluation and Molecular Docking Studies of New N -Heterocyclic Compounds as Aromatase Inhibitors
    Article Snippet: .. Molecular dynamics (MD) simulations were carried out for 100 ns using the crystal structures of aromatase (PDB ID: 3EQM) in conjunction with a POPE membrane model. ..



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    Overlay of the binding poses of compounds 5c , 5e and 5f with the <t>aromatase</t> enzyme. Two-dimensional and three-dimensional interaction profiles of derivatives 5c ( A ), 5e ( B ), and 5f ( C ) with the active site of aromatase (PDB ID: <t>3EQM).</t> Note: High-resolution and enlarged versions of these figures are available in the for detailed inspection .
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    (A) Primary reaction catalyzed by <t>aromatase</t> (red outline) and it is participation in the positive feedback cycle and (B) structure of the flavone scaffold, isoflavanone scaffold, the isoflavanone derivative presented by Bonfield et al., the isoflavanone-adjacent structure presented by Mirzaie et al., and the scaffold of the Mirzaie structure.
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    Image Search Results


    The effect of omentin-1 on the endometrial expression of StAR, cytochrome P450 SCC , and 3βHSD during the oestrous cycle and early pregnancy. The effect of omentin-1 (OMEN; 25, 50, and 100 ng/mL) on protein abundances of steroidogenic acute regulatory protein (StAR; ( A – E )), P450 side-chain cleavage enzyme (P450 SCC ; ( F – J )) and 3β-hydroxysteroid dehydrogenase (3βHSD; ( K – O )) in the in vitro incubated endometrial explants obtained from pigs during early pregnancy (days 10 to 11, 12 to 13, 15 to 16, and 27 to 28) and on days 10 to 12 of the oestrous cycle. Upper panels: representative immunoblots; lower panels: protein content normalized to actin protein; results (arbitrary units) are presented as means ± S.E.M. ( n = 5). Statistically significant differences are presented by different letters ( p < 0.05).

    Journal: International Journal of Molecular Sciences

    Article Title: Omentin-1 Modulates Porcine Endometrial Steroidogenesis and Tissue Remodelling During Early Pregnancy and the Oestrous Cycle

    doi: 10.3390/ijms27177731

    Figure Lengend Snippet: The effect of omentin-1 on the endometrial expression of StAR, cytochrome P450 SCC , and 3βHSD during the oestrous cycle and early pregnancy. The effect of omentin-1 (OMEN; 25, 50, and 100 ng/mL) on protein abundances of steroidogenic acute regulatory protein (StAR; ( A – E )), P450 side-chain cleavage enzyme (P450 SCC ; ( F – J )) and 3β-hydroxysteroid dehydrogenase (3βHSD; ( K – O )) in the in vitro incubated endometrial explants obtained from pigs during early pregnancy (days 10 to 11, 12 to 13, 15 to 16, and 27 to 28) and on days 10 to 12 of the oestrous cycle. Upper panels: representative immunoblots; lower panels: protein content normalized to actin protein; results (arbitrary units) are presented as means ± S.E.M. ( n = 5). Statistically significant differences are presented by different letters ( p < 0.05).

    Article Snippet: P450 AROM , , A2161 (ABclonal, Woburn, MA, USA) , 1:250 , , , 1:2000.

    Techniques: Expressing, In Vitro, Incubation, Western Blot

    The effect of omentin-1 on the endometrial expression of cytochromes P450 C17 and P450 AROM during the oestrous cycle and early pregnancy. The effect of omentin-1 (OMEN; 25, 50, and 100 ng/mL) on protein abundances of cytochrome P450 C17 (P450 C17 ; ( A – E )) and cytochrome P450 aromatase (P450 AROM ; ( F – J )) in the in vitro incubated endometrial explants obtained from pigs during early pregnancy (days 10 to 11, 12 to 13, 15 to 16, and 27 to 28) and on days 10 to 12 of the oestrous cycle. Upper panels: representative immunoblots; lower panels: protein content normalized to actin protein; results (arbitrary units) are presented as means ± S.E.M. ( n = 5). Statistically significant differences are presented by different letters ( p < 0.05).

    Journal: International Journal of Molecular Sciences

    Article Title: Omentin-1 Modulates Porcine Endometrial Steroidogenesis and Tissue Remodelling During Early Pregnancy and the Oestrous Cycle

    doi: 10.3390/ijms27177731

    Figure Lengend Snippet: The effect of omentin-1 on the endometrial expression of cytochromes P450 C17 and P450 AROM during the oestrous cycle and early pregnancy. The effect of omentin-1 (OMEN; 25, 50, and 100 ng/mL) on protein abundances of cytochrome P450 C17 (P450 C17 ; ( A – E )) and cytochrome P450 aromatase (P450 AROM ; ( F – J )) in the in vitro incubated endometrial explants obtained from pigs during early pregnancy (days 10 to 11, 12 to 13, 15 to 16, and 27 to 28) and on days 10 to 12 of the oestrous cycle. Upper panels: representative immunoblots; lower panels: protein content normalized to actin protein; results (arbitrary units) are presented as means ± S.E.M. ( n = 5). Statistically significant differences are presented by different letters ( p < 0.05).

    Article Snippet: P450 AROM , , A2161 (ABclonal, Woburn, MA, USA) , 1:250 , , , 1:2000.

    Techniques: Expressing, In Vitro, Incubation, Western Blot

    Characteristics of the antibodies used in the study.

    Journal: International Journal of Molecular Sciences

    Article Title: Omentin-1 Modulates Porcine Endometrial Steroidogenesis and Tissue Remodelling During Early Pregnancy and the Oestrous Cycle

    doi: 10.3390/ijms27177731

    Figure Lengend Snippet: Characteristics of the antibodies used in the study.

    Article Snippet: P450 AROM , , A2161 (ABclonal, Woburn, MA, USA) , 1:250 , , , 1:2000.

    Techniques: Blocking Assay

    Overlay of the binding poses of compounds 5c , 5e and 5f with the aromatase enzyme. Two-dimensional and three-dimensional interaction profiles of derivatives 5c ( A ), 5e ( B ), and 5f ( C ) with the active site of aromatase (PDB ID: 3EQM). Note: High-resolution and enlarged versions of these figures are available in the for detailed inspection .

    Journal: Pharmaceuticals

    Article Title: Design, Synthesis, Biological Evaluation and Molecular Docking Studies of New N -Heterocyclic Compounds as Aromatase Inhibitors

    doi: 10.3390/ph19020224

    Figure Lengend Snippet: Overlay of the binding poses of compounds 5c , 5e and 5f with the aromatase enzyme. Two-dimensional and three-dimensional interaction profiles of derivatives 5c ( A ), 5e ( B ), and 5f ( C ) with the active site of aromatase (PDB ID: 3EQM). Note: High-resolution and enlarged versions of these figures are available in the for detailed inspection .

    Article Snippet: Molecular dynamics (MD) simulations were carried out for 100 ns using the crystal structures of aromatase (PDB ID: 3EQM) in conjunction with a POPE membrane model.

    Techniques: Binding Assay

    (A) Primary reaction catalyzed by aromatase (red outline) and it is participation in the positive feedback cycle and (B) structure of the flavone scaffold, isoflavanone scaffold, the isoflavanone derivative presented by Bonfield et al., the isoflavanone-adjacent structure presented by Mirzaie et al., and the scaffold of the Mirzaie structure.

    Journal: ACS Omega

    Article Title: Pharmacophoric Investigation of a Natural Product-like Class of Aromatase Inhibitors Using Molecular Modeling

    doi: 10.1021/acsomega.5c07640

    Figure Lengend Snippet: (A) Primary reaction catalyzed by aromatase (red outline) and it is participation in the positive feedback cycle and (B) structure of the flavone scaffold, isoflavanone scaffold, the isoflavanone derivative presented by Bonfield et al., the isoflavanone-adjacent structure presented by Mirzaie et al., and the scaffold of the Mirzaie structure.

    Article Snippet: Molecular dynamics simulations were conducted (see ) of the natural substrate androstenedione (ASD), as well as the three FDA-approved aromatase inhibitors (Exemestane, Letrozole, and Anastrozole) bound to the active site of aromatase.

    Techniques: